Genome location: Pf3D7_10_v3:1,423,666..1,425,959(+)
Genome classification: Core
Product Description: merozoites-associated armadillo repeats protein
SignalP Peptide: MLNIFNIIFLLFLINIYICEA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0009986 | cell surface |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.37 | 0.84 |
| Trophozoite | not expressed | 0.11 | 0.94 |
| Schizont | expressed | 2.30 | 0.26 |
| Gametocyte | not expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1035900
Resistome Missense Mutations: A395V
Resistome Compounds with Missense Mutations: DDD107498
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.732 | MFS: -3.053 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ49
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 3 | 3 | 7 |
| disruptive | 16 | 13 | 10 | 36 |
| missense | 8 | 11 | 9 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 8 | 4 |
| disruptive | 22 | 34 | 20 | 48 |
| missense | 11 | 23 | 16 | 32 |
PlasmoDB Total SNPs: 360
Non-coding: 55 | Synonymous: 163 | Nonsynonymous: 142 | Stop Codon: 0
Protein Length: 566 | Molecular Weight (kDa): 65.151
UniProt ID(s): Q8IJ49
PDB ID(s): None
Isoelectric Point: 3.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 32318061 | Plasmodium falciparum Merozoite Associated Armadillo Protein (PfMAAP) Is ApicallyLocalized in Free Merozoites and Antibodies Are Associated With Reduced Risk ofMalaria. | Aniweh Y, Nyarko PB, ..., Awandare GA | 10.3389/fimmu.2020.00505 |
| 35543215 | Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules | Li Y, Loureiro A, ..., Meunier B | 10.1002/open.202200064 |
| 37896200 | Epidrugs as Promising Tools to Eliminate Plasmodium falciparumArtemisinin-Resistant and Quiescent Parasites | Reyser T, Paloque L, ..., Benoit-Vical F | 10.3390/pharmaceutics15102440 |
| 37655748 | Hybrid molecules based on an emodin scaffold. Synthesis and activity againstSARS-CoV-2 and Plasmodium | Li Y, Touret F, ..., Meunier B | 10.1039/d3ob01122d |
| 38347549 | Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodiumfalciparum | Reyser T, Paloque L, ..., Benoit-Vical F | 10.1186/s12936-024-04855-9 |