Genome location: Pf3D7_10_v3:1,426,843..1,429,332(+)
Genome classification: Core
Product Description: merozoite surface protein 11
SignalP Peptide: MNKFLNIIFYIFLILNFSFFQSNA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0019898 | extrinsic component of membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.23 | 0.90 |
| Trophozoite | expressed | 0.06 | 0.96 |
| Schizont | expressed | 0.77 | 0.68 |
| Gametocyte | possibly expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1036000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.391 | MFS: -2.514 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ48
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 9 | 10 | 18 |
| disruptive | 16 | 21 | 11 | 43 |
| missense | 14 | 20 | 11 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 11 | 15 |
| disruptive | 20 | 37 | 26 | 53 |
| missense | 16 | 31 | 24 | 43 |
PlasmoDB Total SNPs: 75
Non-coding: 62 | Synonymous: 4 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 405 | Molecular Weight (kDa): 46.729
UniProt ID(s): C5HEK0, C5HEK1, C5HEK4, C5HEK5, C5HEK6, C5HEK7, C5HEK8, C5HEK9, C5HEL0, C5HEL4, Q8IJ48
PDB ID(s): None
Isoelectric Point: 4.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010784 | Merozoite surface protein-type |
| PFam | PF07133 | Merozoite surface protein-type |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15664649 | Characterisation of two novel proteins from the asexual stage of Plasmodiumfalciparum, H101 and H103. | Pearce JA, Mills K, ..., Anders RF | 10.1016/j.molbiopara.2004.09.012 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 30385417 | Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion intoerythrocytes in vitro | Tohmoto T, Takashima E, ..., Tsuboi T | 10.1016/j.parint.2018.10.012 |
| 28962616 | Statistical prediction of immunity to placental malaria based on multi-assayantibody data for malarial antigens | Siriwardhana C, Fang R, ..., Chen JJ | 10.1186/s12936-017-2041-3 |
| 25080477 | New antigens for a multicomponent blood-stage malaria vaccine | Osier FH, Mackinnon MJ, ..., Marsh K | 10.1126/scitranslmed.3008705 |
| 36753561 | Anti-merozoite antibodies induce natural killer cell effector function and areassociated with immunity against malaria | Odera DO, Tuju J, ..., Williams TN | 10.1126/scitranslmed.abn5993 |
| 20564187 | Conserved regions from Plasmodium falciparum MSP11 specifically interact withhost cells and have a potential role during merozoite invasion of red bloodcells | Obando-Martinez AZ, Curtidor H, ..., Patarroyo ME | 10.1002/jcb.22600 |
| 35407069 | Structure Identification of Two Polysaccharides from Morchella sextelata withAntioxidant Activity | Li F, Jin Y, Wang J, Xu H | 10.3390/foods11070982 |
| 28716094 | An analytical approach to reduce between-plate variation in multiplex assays thatmeasure antibodies to Plasmodium falciparum antigens | Fang R, Wey A, ..., Chen JJ | 10.1186/s12936-017-1933-6 |