Genome location: Pf3D7_10_v3:1,436,316..1,439,804(+)
Genome classification: Core
Product Description: liver stage antigen 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.01 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1036400
Resistome Missense Mutations: L715R, R723Q, D764E
Resistome Compounds with Missense Mutations: AN13762, MMV668399, NCP26, WLW
Resistome # Samples with Disruptive Mutations: 6 (6 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.5 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1445700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZZD7
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.15) with 1QVR (Global RMSD=30.89)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 18 | 10 | 19 |
| disruptive | 40 | 53 | 20 | 70 |
| missense | 40 | 50 | 19 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 27 | 14 | 28 |
| disruptive | 51 | 88 | 45 | 80 |
| missense | 50 | 78 | 41 | 72 |
PlasmoDB Total SNPs: 531
Non-coding: 0 | Synonymous: 351 | Nonsynonymous: 179 | Stop Codon: 1
Protein Length: 1162 | Molecular Weight (kDa): 138.994
UniProt ID(s): A0A143ZZD7, Q25843, Q25844, Q25846, Q25847, Q25848, Q25849, Q25851, Q25852, Q25886, Q25887, Q25890, Q25891, Q25892, Q25893, Q25894, Q25896, Q25901, Q25902, Q26028
PDB ID(s): None
Isoelectric Point: 4.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR039959 | Fimbrin/Plastin |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 21569184 | Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes adifferentiation defect in late liver-stage parasites. | Mikolajczak SA, Sacci JB Jr, ..., Kappe SH | 10.1111/j.1462-5822.2011.01617.x |
| 28962616 | Statistical prediction of immunity to placental malaria based on multi-assayantibody data for malarial antigens | Siriwardhana C, Fang R, ..., Chen JJ | 10.1186/s12936-017-2041-3 |
| 29016339 | Synthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, andBlood Stages: Naturally Acquired Immune Response and Human Leukocyte AntigenAssociations in Individuals Living in a Brazilian Endemic Area | Pratt-Riccio LR, De Souza Perce-Da-Silva D, ..., Banic DM | 10.4269/ajtmh.17-0359 |
| 33032606 | Malaria serology data from the Guiana shield: first insight in IgG antibodyresponses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariaeantigens in Suriname | Labadie-Bracho MY, van Genderen FT, Adhin MR | 10.1186/s12936-020-03434-y |
| 31931834 | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists innorthern Senegal to assess malaria exposure | Seck MC, Thwing J, ..., Ndiaye D | 10.1186/s12936-020-3114-2 |
| 33124533 | Antibody Correlates of Protection from Clinical Plasmodium falciparum Malaria inan Area of Low and Unstable Malaria Transmission | Hamre KES, Ondigo BN, ..., John CC | 10.4269/ajtmh.18-0805 |
| 36403045 | Characterization of the primary antibody response to Plasmodium falciparumantigens in infants living in a malaria-endemic area | Tassi Yunga S, Siriwardhana C, ..., Taylor DW | 10.1186/s12936-022-04360-x |
| 30949162 | Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T CellEpitopes | Heide J, Vaughan KC, ..., Schulze Zur Wiesch J | 10.3389/fimmu.2019.00397 |
| 32192514 | Practical example of multiple antibody screening for evaluation of malariacontrol strategies | Varela ML, Koffi D, ..., Perraut R | 10.1186/s12936-020-03186-9 |
| 32228699 | Screening for malaria antigen and anti-malarial IgG antibody inforcibly-displaced Myanmar nationals: Cox's Bazar district, Bangladesh, 2018 | Lu A, Cote O, ..., Rogier E | 10.1186/s12936-020-03199-4 |
| 29444078 | Multiplex serology for impact evaluation of bed net distribution on burden oflymphatic filariasis and four species of human malaria in northern Mozambique | Plucinski MM, Candrinho B, ..., Priest JW | 10.1371/journal.pntd.0006278 |
| 35697275 | Cyclic constrained immunoreactive peptides from crucial P. falciparum proteins:potential implications in malaria diagnostics | Vashisht K, Srivastava S, ..., Pandey KC | 10.1016/j.trsl.2022.06.008 |
| 30828645 | Functional antibodies against Plasmodium falciparum sporozoites are associatedwith a longer time to qPCR-detected infection among schoolchildren in BurkinaFaso | Barry A, Behet MC, ..., Goncalves BP | 10.12688/wellcomeopenres.14932.2 |
| 38254075 | Geospatial analysis of Plasmodium falciparum serological indicators: schoolversus community sampling in a low-transmission malaria setting | Jaramillo-Underwood A, Herman C, ..., Rogier E | 10.1186/s12916-023-03145-6 |
| 25604473 | Measuring naturally acquired ex vivo IFN-gamma responses to Plasmodium falciparumcell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults | Anum D, Kusi KA, ..., Sedegah M | 10.1186/s12936-014-0539-5 |
| 31740525 | Preclinical Development and Assessment of Viral Vectors Expressing a FusionAntigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-StageMalaria | Halbroth BR, Sebastian S, ..., Spencer AJ | 10.1128/IAI.00573-19 |
| 31455373 | Sero-identification of the aetiologies of human malaria exposure (Plasmodiumspp.) in the Limu Kossa District of Jimma Zone, South western Ethiopia | Feleke SM, Brhane BG, ..., Cama V | 10.1186/s12936-019-2927-3 |