Genome location: Pf3D7_10_v3:1,445,542..1,447,915(-)
Genome classification: Core
Product Description: phosducin-like protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.11 | 0.93 |
| Schizont | possibly expressed | 0.06 | 0.96 |
| Gametocyte | possibly expressed | 0.17 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1036700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.926 | MFS: -2.399 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0519700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0519700)
Modification: Disrupted | RMgm-2029
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZZR4
"Best" AlphaFill ligand hit: FAR (farnesyl, Local RMSD=0.39) with 1A0R (Global RMSD=5.58)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101215
Most Similar Human Ortholog: O14530
TM-align score: 0.63 | RMSD: 2.20
Seq Identity: 0.38 | Length: 147 / 210
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115514 | thioredoxin domain containing 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 5 | 5 |
| disruptive | 2 | 8 | 9 | 21 |
| missense | 2 | 7 | 9 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 19 | 5 | 10 |
| disruptive | 7 | 27 | 26 | 44 |
| missense | 3 | 20 | 20 | 40 |
PlasmoDB Total SNPs: 104
Non-coding: 100 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 210 | Molecular Weight (kDa): 24.698
UniProt ID(s): A0A143ZZR4
PDB ID(s): None
Isoelectric Point: 6.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR024253 | Phosducin, thioredoxin-like domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF02114 | Phosducin, thioredoxin-like domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22995278 | The evolution and putative function of phosducin-like proteins in the malariaparasite Plasmodium | Putonti C, Quach B, Kooistra RL, Kanzok SM | 10.1016/j.meegid.2012.08.023 |