Genome location: Pf3D7_10_v3:1,447,919..1,451,772(-)
Genome classification: Core
Product Description: acetyl-CoA transporter 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005783 | endoplasmic reticulum |
Component | GO:0016020 | membrane |
Function | GO:0015295 | solute:proton symporter activity |
Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | possibly expressed | 0.08 | 0.96 |
Trophozoite | expressed | 0.45 | 0.73 |
Schizont | expressed | 0.33 | 0.80 |
Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1036800
Resistome Missense Mutations: P65L, K90I, L91I, W93R, A94T, S110R, D165N, I411N, G559R
Resistome Compounds with Missense Mutations: GNF179/KAF179, MMV907364
Resistome # Samples with Disruptive Mutations: 19 (7 missense, 7 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.992 | MFS: -2.771 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0519800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0519800)
Modification: Disrupted | RMgm-5217
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ40
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
---|---|---|---|---|
O00400 | Acetyl-coenzyme A transporter 1 | Homo sapiens | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | US8592431, 124US8592431, 154US8592431, 155US8592431, 2... |
Ortholog Group (OrthoMCL): OG6_101700
Most Similar Human Ortholog: O00400
TM-align score: 0.79 | RMSD: 2.87
Seq Identity: 0.36 | Length: 472 / 590
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000169359 | solute carrier family 33 member 1 |
ENSG00000284952 | novel transcript |
Protein Length: 590 | Molecular Weight (kDa): 69.796
UniProt ID(s): Q8IJ40
PDB ID(s): None
Isoelectric Point: 9.77
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR004752 | AmpG-like permease/Acetyl-coenzyme A transporter 1 |
InterPro | IPR024371 | Acetyl-coenzyme A transporter 1-like |
InterPro | IPR036259 | MFS transporter superfamily |
PFam | PF13000 | Acetyl-coenzyme A transporter 1-like |
Superfamily | SSF103473 | MFS transporter superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 32 | 10 | 20 |
disruptive | 13 | 27 | 11 | 45 |
missense | 12 | 27 | 9 | 34 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 11 | 47 | 10 | 27 |
disruptive | 17 | 61 | 39 | 82 |
missense | 16 | 41 | 32 | 56 |
PlasmoDB Total SNPs: 228
Non-coding: 172 | Synonymous: 44 | Nonsynonymous: 12 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
27642791 | UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistancegenes. | Lim MY, LaMonte G, ..., Bifani P | 10.1038/nmicrobiol.2016.166 |