About Gene List

PF3D7_1036800 (AT1)

Genome location: Pf3D7_10_v3:1,447,919..1,451,772(-)

Genome classification: Core

Function and Localization

Product Description: acetyl-CoA transporter 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005783 endoplasmic reticulum
Component GO:0016020 membrane
Function GO:0015295 solute:proton symporter activity
Process GO:0009410 response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.08 0.96
Trophozoite expressed 0.45 0.73
Schizont expressed 0.33 0.80
Gametocyte expressed 0.29 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1036800

Resistome Missense Mutations: P65L, K90I, L91I, W93R, A94T, S110R, D165N, I411N, G559R

Resistome Compounds with Missense Mutations: GNF179/KAF179, MMV907364

Resistome # Samples with Disruptive Mutations: 19 (7 missense, 7 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.771 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0519800)

  • Relative Growth Rate: 0.82 ± 0.10
  • Confidence: 5.95

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0519800)

Modification: Disrupted | RMgm-5217

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ40

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
O00400 Acetyl-coenzyme A transporter 1 Homo sapiens HOGENOM, OMA, OrthoDB, OrthoMCL BLAST US8592431, 124US8592431, 154US8592431, 155US8592431, 2...

Orthology Information

Ortholog Group (OrthoMCL): OG6_101700

Most Similar Human Ortholog: O00400

TM-align score: 0.79 | RMSD: 2.87

Seq Identity: 0.36 | Length: 472 / 590

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000169359 solute carrier family 33 member 1
ENSG00000284952 novel transcript

Protein Information

Protein Length: 590 | Molecular Weight (kDa): 69.796

UniProt ID(s): Q8IJ40

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004752 AmpG-like permease/Acetyl-coenzyme A transporter 1
InterPro IPR024371 Acetyl-coenzyme A transporter 1-like
InterPro IPR036259 MFS transporter superfamily
PFam PF13000 Acetyl-coenzyme A transporter 1-like
Superfamily SSF103473 MFS transporter superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 32 10 20
disruptive 13 27 11 45
missense 12 27 9 34

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 47 10 27
disruptive 17 61 39 82
missense 16 41 32 56

PlasmoDB Total SNPs: 228

Non-coding: 172 | Synonymous: 44 | Nonsynonymous: 12 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27642791 UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistancegenes. Lim MY, LaMonte G, ..., Bifani P 10.1038/nmicrobiol.2016.166