About Gene List

PF3D7_1037200

Genome location: Pf3D7_10_v3:1,473,514..1,476,860(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.04 0.98
Schizont possibly expressed 0.03 0.98
Gametocyte expressed 0.23 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1037200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -0.579 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0520100)

  • Relative Growth Rate: 0.84 ± 0.18
  • Confidence: 4.85

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0520100)

Modification: Disrupted | RMgm-2033

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1X7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532947

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 37 18 27
disruptive 11 71 34 96
missense 11 71 34 84

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 60 24 41
disruptive 30 146 65 153
missense 27 122 57 109

PlasmoDB Total SNPs: 168

Non-coding: 131 | Synonymous: 23 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 708 | Molecular Weight (kDa): 84.455

UniProt ID(s): A0A144A1X7

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094