About Gene List

PF3D7_1037300 (AAC1)

Genome location: Pf3D7_10_v3:1,476,917..1,480,703(-)

Genome classification: Core

Function and Localization

Product Description: ADP,ATP carrier protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0020020 food vacuole
Component GO:0005743 mitochondrial inner membrane
Component GO:0005739 mitochondrion
Function GO:0005471 ATP:ADP antiporter activity
Function GO:0003723 RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.33 0.84
Trophozoite expressed 0.99 0.49
Schizont expressed 0.13 0.92
Gametocyte expressed 0.45 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1037300

Resistome Missense Mutations: I119S, I301N

Resistome Compounds with Missense Mutations: GNF-Pf4492/NITD358, KAE678/NITD678

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.537 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0520200)

  • Relative Growth Rate: 0.21 ± 0.09
  • Confidence: 6.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0520200)

Modification: Disrupted | RMgm-2034

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ34

"Best" AlphaFill ligand hit: CM5 (cymal-5, Local RMSD=0.23) with 4C9H (Global RMSD=2.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100505

Most Similar Human Ortholog: P05141

TM-align score: 0.96 | RMSD: 1.17

Seq Identity: 0.62 | Length: 296 / 301

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000005022 solute carrier family 25 member 5
ENSG00000151475 solute carrier family 25 member 31
ENSG00000151729 solute carrier family 25 member 4
ENSG00000169100 solute carrier family 25 member 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 1 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 265

Non-coding: 257 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 301 | Molecular Weight (kDa): 33.726

UniProt ID(s): Q25692, Q26006, Q8IJ34

PDB ID(s): None

Isoelectric Point: 10.15

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002067 Mitochondrial carrier protein
InterPro IPR002113 ADP/ATP carrier protein, eucaryote
InterPro IPR018108 Mitochondrial substrate/solute carrier
InterPro IPR023395 Mitochondrial carrier domain superfamily
PFam PF00153 Mitochondrial substrate/solute carrier
Superfamily SSF103506 Mitochondrial carrier domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
21136929 Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, Tastet C, ..., Dubremetz JF 10.1002/prca.200700112
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606
32574727 Characterization of mitochondrial carrier proteins of malaria parasite Plasmodiumfalciparum based on in vitro translation and reconstitution. Nozawa A, Ito D, ..., Tozawa Y 10.1016/j.parint.2020.102160
33906926 Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH Sinha A, Baumgarten S, ..., Scherf A 10.1128/mBio.00661-21
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21
26577769 Human lactoferrin triggers a mitochondrial- and caspase-dependent regulated celldeath in Saccharomyces cerevisiae Acosta-Zaldivar M, Andres MT, ..., Corte-Real M 10.1007/s10495-015-1199-9
33859735 Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition Jaiquel Baron S, King MS, Kunji ERS, Schirris TJJ 10.7150/thno.54936