Genome location: Pf3D7_10_v3:1,476,917..1,480,703(-)
Genome classification: Core
Product Description: ADP,ATP carrier protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0009986 | cell surface |
Component | GO:0020020 | food vacuole |
Component | GO:0005743 | mitochondrial inner membrane |
Component | GO:0005739 | mitochondrion |
Function | GO:0005471 | ATP:ADP antiporter activity |
Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.33 | 0.84 |
Trophozoite | expressed | 0.99 | 0.49 |
Schizont | expressed | 0.13 | 0.92 |
Gametocyte | expressed | 0.45 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1037300
Resistome Missense Mutations: I119S, I301N
Resistome Compounds with Missense Mutations: GNF-Pf4492/NITD358, KAE678/NITD678
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.178 | MFS: -2.537 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0520200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0520200)
Modification: Disrupted | RMgm-2034
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ34
"Best" AlphaFill ligand hit: CM5 (cymal-5, Local RMSD=0.23) with 4C9H (Global RMSD=2.02)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100505
Most Similar Human Ortholog: P05141
TM-align score: 0.96 | RMSD: 1.17
Seq Identity: 0.62 | Length: 296 / 301
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000005022 | solute carrier family 25 member 5 |
ENSG00000151475 | solute carrier family 25 member 31 |
ENSG00000151729 | solute carrier family 25 member 4 |
ENSG00000169100 | solute carrier family 25 member 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 0 | 0 | 0 | 1 |
missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 0 | 0 | 0 |
disruptive | 0 | 1 | 0 | 0 |
missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 265
Non-coding: 257 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 301 | Molecular Weight (kDa): 33.726
UniProt ID(s): Q25692, Q26006, Q8IJ34
PDB ID(s): None
Isoelectric Point: 10.15
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR002067 | Mitochondrial carrier protein |
InterPro | IPR002113 | ADP/ATP carrier protein, eucaryote |
InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
PFam | PF00153 | Mitochondrial substrate/solute carrier |
Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
32574727 | Characterization of mitochondrial carrier proteins of malaria parasite Plasmodiumfalciparum based on in vitro translation and reconstitution. | Nozawa A, Ito D, ..., Tozawa Y | 10.1016/j.parint.2020.102160 |
33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
26577769 | Human lactoferrin triggers a mitochondrial- and caspase-dependent regulated celldeath in Saccharomyces cerevisiae | Acosta-Zaldivar M, Andres MT, ..., Corte-Real M | 10.1007/s10495-015-1199-9 |
33859735 | Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition | Jaiquel Baron S, King MS, Kunji ERS, Schirris TJJ | 10.7150/thno.54936 |