PF3D7_1037400

Genome location: Pf3D7_10_v3:1,481,557..1,486,315(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0006513	protein monoubiquitination
Process	GO:0000209	protein polyubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.09	0.95
Trophozoite	expressed	0.34	0.81
Schizont	expressed	0.76	0.62
Gametocyte	expressed	0.52	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1037400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.156 | MFS: -3.201 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ33

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533657

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	49	25	58
disruptive	46	192	82	199
missense	38	177	80	174

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	106	44	66
disruptive	105	394	139	305
missense	72	318	113	191

PlasmoDB Total SNPs: 194

Non-coding: 68 | Synonymous: 72 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 1196 | Molecular Weight (kDa): 145.148

UniProt ID(s): Q8IJ33

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A