Genome location: Pf3D7_10_v3:1,487,741..1,490,305(+)
Genome classification: Core
Product Description: dynamin-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0000266 | mitochondrial fission |
| Process | GO:0048285 | organelle fission |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.15 | 0.91 |
| Schizont | expressed | 1.02 | 0.53 |
| Gametocyte | possibly expressed | 0.44 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1037500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -3.127 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0520400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0520400)
Modification: Disrupted | RMgm-2035
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ32
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.56) with 1JWY (Global RMSD=3.85)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O00429 | Dynamin-1-like protein | OMA, OrthoDB | US11168080, Compound A-1US11168080, Compound A-3US11168080, Compound A-3BDBM524245... | |
| P50570 | Dynamin-2 | Homo sapiens | OrthoDB | CHEMBL1094850CHEMBL1098764CHEMBL1094197CHEMBL4094056... |
| P39052 | Dynamin-2 | Rattus norvegicus | OrthoDB | CHEMBL3329968CHEMBL2312430 |
| Q05193 | Dynamin-1 | Homo sapiens | OrthoDB | Tetradonium bromideTetradonium bromideTetradecyl-ammoniumbromide... |
Ortholog Group (OrthoMCL): OG6_100232
Most Similar Human Ortholog: K7EPK9
TM-align score: 0.96 | RMSD: 0.48
Seq Identity: 0.56 | Length: 50 / 709
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000079805 | dynamin 2 |
| ENSG00000087470 | dynamin 1 like |
| ENSG00000106976 | dynamin 1 |
| ENSG00000197959 | dynamin 3 |
Protein Length: 709 | Molecular Weight (kDa): 81.526
PDB ID(s): None
Isoelectric Point: 6.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000375 | Dynamin central domain |
| InterPro | IPR001401 | Dynamin, GTPase domain |
| InterPro | IPR003130 | Dynamin GTPase effector |
| InterPro | IPR022812 | Dynamin superfamily |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00350 | Dynamin superfamily |
| PFam | PF01031 | Dynamin central domain |
| PFam | PF02212 | Dynamin GTPase effector |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 24 | 17 | 26 |
| disruptive | 3 | 14 | 4 | 19 |
| missense | 3 | 13 | 4 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 62 | 14 | 24 |
| disruptive | 7 | 31 | 23 | 85 |
| missense | 6 | 24 | 17 | 51 |
PlasmoDB Total SNPs: 55
Non-coding: 31 | Synonymous: 20 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17533148 | Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparumexpressed in schizonts. | Charneau S, Bastos IM, ..., Florent I | 10.1016/j.micinf.2007.02.020 |
| 35064377 | Lipopolysaccharide Accelerates Neuropilin-1 Protein Degradation by Activating theLarge GTPase Dynamin-1 in Macrophages | Wu S, Huang Y, Huang X, Dai X | 10.1007/s10753-021-01610-z |
| 34428626 | Molecular basis of synchronous replication of malaria parasites in the bloodstage | Dos Santos BM, Pereira PH, Garcia CR | 10.1016/j.mib.2021.08.002 |
| 37490041 | The yeast RNA methylation complex consists of conserved yet reconfiguredcomponents with m6A-dependent and independent roles | Ensinck I, Maman A, ..., van Werven FJ | 10.7554/eLife.87860 |