Genome location: Pf3D7_10_v3:1,495,330..1,496,999(+)
Genome classification: Core
Product Description: enhancer of rudimentary homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.22 | 0.89 |
| Trophozoite | not expressed | 0.27 | 0.83 |
| Schizont | possibly expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1037700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.466 | MFS: -2.772 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ30
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103598
Most Similar Human Ortholog: P84090
TM-align score: 0.94 | RMSD: 0.88
Seq Identity: 0.33 | Length: 101 / 105
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100632 | ERH mRNA splicing and mitosis factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 57
Non-coding: 54 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 105 | Molecular Weight (kDa): 12.32
UniProt ID(s): Q8IJ30
PDB ID(s): None
Isoelectric Point: 8.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000781 | Enhancer of rudimentary |
| InterPro | IPR035912 | Enhancer of rudimentary superfamily |
| PFam | PF01133 | Enhancer of rudimentary |
| Superfamily | SSF143875 | Enhancer of rudimentary superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |