Product Description: WD repeat-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005858 | axonemal dynein complex |
| Function | GO:0045504 | dynein heavy chain binding |
| Function | GO:0045503 | dynein light chain binding |
| Process | GO:0003341 | cilium movement |
| Process | GO:0007018 | microtubule-based movement |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.04 | 0.97 |
| Gametocyte | not expressed | 0.36 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1037800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.994 | MFS: -2.085 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ29
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104391
Most Similar Human Ortholog: H0YEC9
TM-align score: 0.76 | RMSD: 2.88
Seq Identity: 0.23 | Length: 127 / 944
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000162643 | dynein axonemal intermediate chain 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 49 | 12 | 53 |
| disruptive | 10 | 91 | 52 | 108 |
| missense | 9 | 91 | 50 | 101 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 74 | 35 | 54 |
| disruptive | 27 | 198 | 77 | 205 |
| missense | 20 | 167 | 69 | 154 |
PlasmoDB Total SNPs: 287
Non-coding: 229 | Synonymous: 42 | Nonsynonymous: 15 | Stop Codon: 1
Protein Length: 944 | Molecular Weight (kDa): 111.699
UniProt ID(s): Q8IJ29
PDB ID(s): None
Isoelectric Point: 8.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |