About Gene List

PF3D7_1037900

Genome location: Pf3D7_10_v3:1,502,362..1,504,802(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.11 0.94
Trophozoite no data 0.29 0.83
Schizont no data 0.28 0.81
Gametocyte no data 0.33 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1037900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.074 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3E3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533134

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 9 3 6
disruptive 4 17 7 16
missense 4 16 6 14

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 15 3 11
disruptive 9 39 11 36
missense 9 25 9 19

PlasmoDB Total SNPs: 118

Non-coding: 102 | Synonymous: 14 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 182 | Molecular Weight (kDa): 21.486

UniProt ID(s): C6S3E3

PDB ID(s): None

Isoelectric Point: 10.33

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21