About Gene List

PF3D7_1038100

Genome location: Pf3D7_10_v3:1,507,084..1,510,762(-)

Genome classification: Core

Function and Localization

Product Description: GDP dissociation inhibitor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005968 Rab-protein geranylgeranyltransferase complex
Component GO:0005737 cytoplasm
Component GO:0005829 cytosol
Component GO:0005634 nucleus
Process GO:0018344 protein geranylgeranylation
Process GO:0016192 vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.21 0.90
Trophozoite expressed 0.50 0.72
Schizont possibly expressed 0.14 0.91
Gametocyte expressed 0.47 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.024 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ27

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533666

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 40 18 57
disruptive 79 187 73 162
missense 37 148 60 122

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 85 22 79
disruptive 138 321 116 259
missense 72 245 84 162

PlasmoDB Total SNPs: 139

Non-coding: 21 | Synonymous: 68 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 980 | Molecular Weight (kDa): 116.176

UniProt ID(s): Q8IJ27

PDB ID(s): None

Isoelectric Point: 5.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR018203 GDP dissociation inhibitor
InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
PFam PF00996 GDP dissociation inhibitor
Superfamily SSF51905 FAD/NAD(P)-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097