PF3D7_1038100

Genome location: Pf3D7_10_v3:1,507,084..1,510,762(-)

Genome classification: Core

Function and Localization

Product Description: GDP dissociation inhibitor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005968	Rab-protein geranylgeranyltransferase complex
Component	GO:0005737	cytoplasm
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Process	GO:0018344	protein geranylgeranylation
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.21	0.90
Trophozoite	expressed	0.50	0.72
Schizont	possibly expressed	0.14	0.91
Gametocyte	expressed	0.47	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.024 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ27

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533666

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	40	18	57
disruptive	79	187	73	162
missense	37	148	60	122

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	85	22	79
disruptive	138	321	116	259
missense	72	245	84	162

PlasmoDB Total SNPs: 139

Non-coding: 21 | Synonymous: 68 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 980 | Molecular Weight (kDa): 116.176

UniProt ID(s): Q8IJ27

PDB ID(s): None

Isoelectric Point: 5.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018203	GDP dissociation inhibitor
InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
PFam	PF00996	GDP dissociation inhibitor
Superfamily	SSF51905	FAD/NAD(P)-binding domain superfamily