Product Description: GDP dissociation inhibitor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005968 | Rab-protein geranylgeranyltransferase complex |
Component | GO:0005737 | cytoplasm |
Component | GO:0005829 | cytosol |
Component | GO:0005634 | nucleus |
Process | GO:0018344 | protein geranylgeranylation |
Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | possibly expressed | 0.21 | 0.90 |
Trophozoite | expressed | 0.50 | 0.72 |
Schizont | possibly expressed | 0.14 | 0.91 |
Gametocyte | expressed | 0.47 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1038100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.024 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ27
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 11 | 40 | 18 | 57 |
disruptive | 79 | 187 | 73 | 162 |
missense | 37 | 148 | 60 | 122 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 16 | 85 | 22 | 79 |
disruptive | 138 | 321 | 116 | 259 |
missense | 72 | 245 | 84 | 162 |
PlasmoDB Total SNPs: 139
Non-coding: 21 | Synonymous: 68 | Nonsynonymous: 50 | Stop Codon: 0
Protein Length: 980 | Molecular Weight (kDa): 116.176
UniProt ID(s): Q8IJ27
PDB ID(s): None
Isoelectric Point: 5.25
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR018203 | GDP dissociation inhibitor |
InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
PFam | PF00996 | GDP dissociation inhibitor |
Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |