PF3D7_1038300

Genome location: Pf3D7_10_v3:1,512,190..1,514,416(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	0.99
Schizont	no data	0.00	1.00
Gametocyte	no data	0.40	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.712 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0B2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112431

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	25	4	10
disruptive	7	32	9	52
missense	7	31	9	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	24	12	17
disruptive	15	74	27	83
missense	9	61	24	64

PlasmoDB Total SNPs: 119

Non-coding: 98 | Synonymous: 12 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 366 | Molecular Weight (kDa): 42.164

UniProt ID(s): A0A144A0B2

PDB ID(s): None

Isoelectric Point: 9.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52047	N/A