About Gene List

PF3D7_1038400 (Pf11-1)

Genome location: Pf3D7_10_v3:1,518,290..1,548,390(+)

Genome classification: Core

Function and Localization

Product Description: gametocyte-specific protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm
Process GO:0007276 gamete generation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.07 0.97
Trophozoite expressed 0.14 0.93
Schizont expressed 0.11 0.94
Gametocyte expressed 1.92 0.31

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038400

Resistome Missense Mutations: K2978Q

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 4 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.25 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533663

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 68 221 69 157
disruptive 280 874 411 866
missense 216 712 328 594

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 127 333 105 160
disruptive 521 1479 608 1151
missense 415 1162 409 586

PlasmoDB Total SNPs: 9023

Non-coding: 60 | Synonymous: 5063 | Nonsynonymous: 3900 | Stop Codon: 0

Protein Information

Protein Length: 9563 | Molecular Weight (kDa): 1099.259

UniProt ID(s): Q8I6U6, V9H1E6

PDB ID(s): None

Isoelectric Point: 3.26

Protein Domain Annotations:

Source Family ID Description
InterPro IPR010867 NPR nonapeptide
PFam PF07391 NPR nonapeptide
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
1600948 Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage andhealing: identification of a gametocyte-specific protein with a potential role ingametogenesis. Scherf A, Carter R, ..., Leech J 10.1002/j.1460-2075.1992.tb05288.x
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
7686855 Immune response in mouse and malaria-exposed humans to peptides derived fromPf11-1, a highly repetitive megadalton protein of Plasmodium falciparum Scherf A, Behr C, ..., Dubois P 10.1002/eji.1830230727
7504999 Analysis of a human monoclonal antibody reactive with multiple Plasmodiumfalciparum antigen repeat sequences using a solid phase affinity assay Ahlborg N, Larsson A, Perlmann P, Berzins K 10.1016/0165-2478(93)90019-x
1730474 Involvement of Pf155/RESA and cross-reactive antigens in Plasmodium falciparummerozoite invasion in vitro Wahlin B, Sjolander A, ..., Perlmann P 10.1128/iai.60.2.443-449.1992
12572016 Cloning and expressing of the three repeat fragments of Plasmodium falciparum11.1 gene Hu W, Yamasaki T, ..., Wang JJ https://pubmed.ncbi.nlm.nih.gov/12572016/
7692377 Epitope specificity and capacity to inhibit parasite growth in vitro of humanantibodies to repeat sequences of the Plasmodium falciparum antigen Ag332 Ahlborg N, Flyg BW, ..., Berzins K 10.1111/j.1365-3024.1993.tb00624.x
8888729 Plasmodium falciparum: genetic diversity of several strains infectious for thesquirrel monkey (Saimiri sciureus) Fandeur T, Mercereau-Puijalon O, Bonnemains B 10.1006/expr.1996.0085
22059951 Assessment of exposure to Plasmodium falciparum transmission in a low endemicityarea by using multiplex fluorescent microsphere-based serological assays Sarr JB, Orlandi-Pradines E, ..., Remoue F 10.1186/1756-3305-4-212
7628570 Plasmodium falciparum: D260, an intraerythrocytic parasite protein, is a memberof the glutamic acid dipeptide-repeat family of proteins Barnes DA, Wollish W, ..., Petersen C 10.1006/expr.1995.1095
21059211 A multiplex assay for the simultaneous detection of antibodies against 15Plasmodium falciparum and Anopheles gambiae saliva antigens Ambrosino E, Dumoulin C, ..., Rogier C 10.1186/1475-2875-9-317
1712912 Definition of the epitope recognized by the Plasmodium falciparum-reactive humanmonoclonal antibody 33G2 Ahlborg N, Berzins K, Perlmann P 10.1016/0166-6851(91)90202-h
2654292 Reactivity of the human monoclonal antibody 33G2 with repeated sequences of threedistinct Plasmodium falciparum antigens Udomsangpetch R, Carlsson J, ..., et al. https://pubmed.ncbi.nlm.nih.gov/2654292/
2905138 Structure and function of a thymic peptide is mimicked by Plasmodium falciparumpeptides Dubois P, Dardenne M, ..., Pereira da Silva L 10.1016/0769-2625(88)90100-6
1343731 Characterization of a Plasmodium falciparium mutant that has deleted the majorityof the gametocyte-specific Pf11-1 locus Scherf A, Petersen C, ..., Leech J 10.1590/s0074-02761992000700012
9293771 Predominance of H-2d- and H-2k-restricted T-cell epitopes in the highlyrepetitive Plasmodium falciparum antigen Pf332 Ahlborg N, Sterky F, ..., Berzins K 10.1016/s0161-5890(97)00046-1