Genome location: Pf3D7_10_v3:1,518,290..1,548,390(+)
Genome classification: Core
Product Description: gametocyte-specific protein
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0030430 | host cell cytoplasm |
Process | GO:0007276 | gamete generation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.07 | 0.97 |
Trophozoite | expressed | 0.14 | 0.93 |
Schizont | expressed | 0.11 | 0.94 |
Gametocyte | expressed | 1.92 | 0.31 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1038400
Resistome Missense Mutations: K2978Q
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 4 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.25 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 68 | 221 | 69 | 157 |
disruptive | 280 | 874 | 411 | 866 |
missense | 216 | 712 | 328 | 594 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 127 | 333 | 105 | 160 |
disruptive | 521 | 1479 | 608 | 1151 |
missense | 415 | 1162 | 409 | 586 |
PlasmoDB Total SNPs: 9023
Non-coding: 60 | Synonymous: 5063 | Nonsynonymous: 3900 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
1600948 | Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage andhealing: identification of a gametocyte-specific protein with a potential role ingametogenesis. | Scherf A, Carter R, ..., Leech J | 10.1002/j.1460-2075.1992.tb05288.x |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
7686855 | Immune response in mouse and malaria-exposed humans to peptides derived fromPf11-1, a highly repetitive megadalton protein of Plasmodium falciparum | Scherf A, Behr C, ..., Dubois P | 10.1002/eji.1830230727 |
7504999 | Analysis of a human monoclonal antibody reactive with multiple Plasmodiumfalciparum antigen repeat sequences using a solid phase affinity assay | Ahlborg N, Larsson A, Perlmann P, Berzins K | 10.1016/0165-2478(93)90019-x |
1730474 | Involvement of Pf155/RESA and cross-reactive antigens in Plasmodium falciparummerozoite invasion in vitro | Wahlin B, Sjolander A, ..., Perlmann P | 10.1128/iai.60.2.443-449.1992 |
12572016 | Cloning and expressing of the three repeat fragments of Plasmodium falciparum11.1 gene | Hu W, Yamasaki T, ..., Wang JJ | https://pubmed.ncbi.nlm.nih.gov/12572016/ |
7692377 | Epitope specificity and capacity to inhibit parasite growth in vitro of humanantibodies to repeat sequences of the Plasmodium falciparum antigen Ag332 | Ahlborg N, Flyg BW, ..., Berzins K | 10.1111/j.1365-3024.1993.tb00624.x |
8888729 | Plasmodium falciparum: genetic diversity of several strains infectious for thesquirrel monkey (Saimiri sciureus) | Fandeur T, Mercereau-Puijalon O, Bonnemains B | 10.1006/expr.1996.0085 |
22059951 | Assessment of exposure to Plasmodium falciparum transmission in a low endemicityarea by using multiplex fluorescent microsphere-based serological assays | Sarr JB, Orlandi-Pradines E, ..., Remoue F | 10.1186/1756-3305-4-212 |
7628570 | Plasmodium falciparum: D260, an intraerythrocytic parasite protein, is a memberof the glutamic acid dipeptide-repeat family of proteins | Barnes DA, Wollish W, ..., Petersen C | 10.1006/expr.1995.1095 |
21059211 | A multiplex assay for the simultaneous detection of antibodies against 15Plasmodium falciparum and Anopheles gambiae saliva antigens | Ambrosino E, Dumoulin C, ..., Rogier C | 10.1186/1475-2875-9-317 |
1712912 | Definition of the epitope recognized by the Plasmodium falciparum-reactive humanmonoclonal antibody 33G2 | Ahlborg N, Berzins K, Perlmann P | 10.1016/0166-6851(91)90202-h |
2654292 | Reactivity of the human monoclonal antibody 33G2 with repeated sequences of threedistinct Plasmodium falciparum antigens | Udomsangpetch R, Carlsson J, ..., et al. | https://pubmed.ncbi.nlm.nih.gov/2654292/ |
2905138 | Structure and function of a thymic peptide is mimicked by Plasmodium falciparumpeptides | Dubois P, Dardenne M, ..., Pereira da Silva L | 10.1016/0769-2625(88)90100-6 |
1343731 | Characterization of a Plasmodium falciparium mutant that has deleted the majorityof the gametocyte-specific Pf11-1 locus | Scherf A, Petersen C, ..., Leech J | 10.1590/s0074-02761992000700012 |
9293771 | Predominance of H-2d- and H-2k-restricted T-cell epitopes in the highlyrepetitive Plasmodium falciparum antigen Pf332 | Ahlborg N, Sterky F, ..., Berzins K | 10.1016/s0161-5890(97)00046-1 |