About Gene List

PF3D7_1038600

Genome location: Pf3D7_10_v3:1,551,088..1,553,687(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.03 0.99
Trophozoite possibly expressed 0.03 0.98
Schizont not expressed 0.05 0.97
Gametocyte not expressed 0.21 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.751 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ25

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532485

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 27 7 20
disruptive 20 37 18 79
missense 20 33 16 76

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 37 13 23
disruptive 31 86 53 99
missense 23 75 44 81

PlasmoDB Total SNPs: 65

Non-coding: 24 | Synonymous: 20 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 518 | Molecular Weight (kDa): 63.094

UniProt ID(s): Q8IJ25

PDB ID(s): None

Isoelectric Point: 6.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12