PF3D7_1038800

Genome location: Pf3D7_10_v3:1,556,587..1,561,332(+)

Genome classification: Core

Function and Localization

Product Description: RESA-like protein with PHIST and DnaJ domains

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030430	host cell cytoplasm
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.54	0.75
Trophozoite	possibly expressed	0.18	0.90
Schizont	possibly expressed	0.12	0.92
Gametocyte	not expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1038800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.763 | #Insertions: 4

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1238200)

Relative Growth Rate: 0.78 ± 0.07
Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ23

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	26	13	27
disruptive	26	120	67	143
missense	25	115	65	126

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	45	20	45
disruptive	49	244	94	204
missense	41	218	82	142

PlasmoDB Total SNPs: 144

Non-coding: 88 | Synonymous: 26 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 911 | Molecular Weight (kDa): 107.583

UniProt ID(s): Q8IJ23

PDB ID(s): None

Isoelectric Point: 8.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR019111	Plasmodium RESA, N-terminal
InterPro	IPR026894	DNAJ-containing protein, X-domain
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
PFam	PF09687	Plasmodium RESA, N-terminal
PFam	PF14308	DNAJ-containing protein, X-domain
Superfamily	SSF46565	Chaperone J-domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
21908595	An erythrocyte cytoskeleton-binding motif in exported Plasmodium falciparumproteins.	Kilili GK, LaCount DJ	10.1128/EC.05180-11