PF3D7_1039800 (EPF3)

Genome location: Pf3D7_10_v3:1,594,503..1,595,277(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: exported protein family 3

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0030430	host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	1.00
Trophozoite	no data	nd	1.00
Schizont	no data	nd	1.00
Gametocyte	no data	nd	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1039800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.795 | MFS: -2.707 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128718

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 35

Non-coding: 5 | Synonymous: 27 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 230 | Molecular Weight (kDa): 27.137

UniProt ID(s): O97474

PDB ID(s): None

Isoelectric Point: 5.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006410	Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
PFam	PF09715	Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
Superfamily	N/A	N/A