About Gene List

PF3D7_1040200

Genome location: Pf3D7_10_v3:1,605,876..1,607,228(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MKMYYLKMILFNFLINTLL

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0033644 host cell membrane
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.00 1.00
Trophozoite expressed 0.01 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte possibly expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1040200

Resistome Missense Mutations: E93Q, N106H, S107T

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.26 | MFS: -2.605 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ07

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 551

Non-coding: 144 | Synonymous: 93 | Nonsynonymous: 314 | Stop Codon: 0

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 34.257

UniProt ID(s): O96495, Q2XR20, Q2XR21, Q2XR22, Q8IJ07, Q9BMD3

PDB ID(s): None

Isoelectric Point: 8.6

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
18474651 Plasmodium falciparum STEVOR proteins are highly expressed in patient isolatesand located in the surface membranes of infected red blood cells and the apicaltips of merozoites. Blythe JE, Yam XY, ..., Preiser PR 10.1128/IAI.01460-07
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004
31363031 Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family Wichers JS, Scholz JAM, ..., Bachmann A 10.1128/mBio.01500-19