Genome location: Pf3D7_10_v3:1,609,063..1,610,422(+)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: MKFNYTNIILFSLSLNILLLSS
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Process | GO:0020033 | antigenic variation |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | possibly expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1040300
Resistome Missense Mutations: T78S
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.295 | MFS: -2.484 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ06
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 664
Non-coding: 67 | Synonymous: 161 | Nonsynonymous: 429 | Stop Codon: 7
Protein Length: 378 | Molecular Weight (kDa): 41.997
UniProt ID(s): Q8IJ06
PDB ID(s): None
Isoelectric Point: 8.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25751816 | RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. | Goel S, Palmkvist M, ..., Wahlgren M | 10.1038/nm.3812 |