About Gene List

PF3D7_1102200 (ECIJP)

Genome location: Pf3D7_11_v3:105,357..107,235(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte cytoskeleton-interacting J protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0044164 host cell cytosol
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.15 0.92
Trophozoite not expressed 0.04 0.98
Schizont not expressed 0.05 0.97
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1102200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.651 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1238200)

  • Relative Growth Rate: 0.78 ± 0.07
  • Confidence: 6.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIX8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 90

Non-coding: 7 | Synonymous: 65 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 566 | Molecular Weight (kDa): 67.273

UniProt ID(s): Q8IIX8

PDB ID(s): None

Isoelectric Point: 7.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR018253 DnaJ domain, conserved site
InterPro IPR026894 DNAJ-containing protein, X-domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
PFam PF14308 DNAJ-containing protein, X-domain
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
34890056 Plasmodium falciparum HSP40 protein eCiJp traffics to the erythrocytecytoskeleton and interacts with the human HSP70 chaperone HSPA1. Sahu W, Bai T, ..., Reddy KS 10.1002/1873-3468.14255