About Gene List

PF3D7_1102300

Genome location: Pf3D7_11_v3:109,829..111,884(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044538 host cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite possibly expressed 0.04 0.98
Schizont possibly expressed 0.02 0.99
Gametocyte possibly expressed 0.29 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1102300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.745 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532807

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 11 7 13
disruptive 31 66 24 78
missense 20 47 14 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 21 8 17
disruptive 48 108 42 94
missense 30 77 28 43

PlasmoDB Total SNPs: 114

Non-coding: 21 | Synonymous: 56 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 415 | Molecular Weight (kDa): 53.487

UniProt ID(s): Q8IIX7

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213