About Gene List

PF3D7_1102500 (GEXP02)

Genome location: Pf3D7_11_v3:118,504..122,768(-)

Genome classification: Core

Function and Localization

Product Description: gametocyte exported protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0033644 host cell membrane
Component GO:0044538 host cell periphery
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.21 0.91
Trophozoite expressed 0.17 0.93
Schizont expressed 0.08 0.96
Gametocyte not expressed 0.94 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1102500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.234 | MFS: -2.787 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIX5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 17 9 26
disruptive 26 73 30 80
missense 26 73 28 72

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 33 16 26
disruptive 33 123 53 129
missense 31 114 49 100

PlasmoDB Total SNPs: 161

Non-coding: 111 | Synonymous: 18 | Nonsynonymous: 31 | Stop Codon: 1

Protein Information

Protein Length: 624 | Molecular Weight (kDa): 73.889

UniProt ID(s): Q8IIX5

PDB ID(s): None

Isoelectric Point: 5.82

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25106850 A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. Tarr SJ, Moon RW, Hardege I, Osborne AR 10.1016/j.molbiopara.2014.07.011
31652487 The PHIST protein GEXP02 targets the host cytoskeleton during sexual developmentof Plasmodium falciparum. Warncke JD, Passecker A, ..., Beck HP 10.1111/cmi.13123
31601834 Reporter lines based on the gexp02 promoter enable early quantification of sexualconversion rates in the malaria parasite Plasmodium falciparum Portugaliza HP, Llora-Batlle O, Rosanas-Urgell A, Cortes A 10.1038/s41598-019-50768-y