About Gene List

PF3D7_1102600 (GEXP14)

Genome location: Pf3D7_11_v3:123,216..124,749(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.92
Trophozoite not expressed 0.06 0.97
Schizont not expressed 0.02 0.99
Gametocyte not expressed 0.21 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1102600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.399 | MFS: -2.549 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIX4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533282

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 4 5 10
disruptive 22 30 12 31
missense 20 30 12 25

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 14 6 18
disruptive 28 58 20 53
missense 26 50 18 32

PlasmoDB Total SNPs: 99

Non-coding: 69 | Synonymous: 7 | Nonsynonymous: 22 | Stop Codon: 1

Protein Information

Protein Length: 271 | Molecular Weight (kDa): 32.328

UniProt ID(s): Q8IIX4

PDB ID(s): None

Isoelectric Point: 8.83

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12