About Gene List

PF3D7_1102700 (ETRAMP11.1)

Genome location: Pf3D7_11_v3:127,762..130,186(+)

Genome classification: Core

Function and Localization

Product Description: early transcribed membrane protein 11.1

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020005 symbiont-containing vacuole membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 3.34 0.06
Trophozoite expressed 1.01 0.53
Schizont expressed 0.80 0.59
Gametocyte expressed 0.54 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1102700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0524800)

  • Relative Growth Rate: 0.97 ± 0.19
  • Confidence: 4.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q7KQK8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_141182

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 202

Non-coding: 196 | Synonymous: 2 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 91 | Molecular Weight (kDa): 10.192

UniProt ID(s): Q7KQK8, Q9NFH1

PDB ID(s): None

Isoelectric Point: 11.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006389 Early transcribed membrane protein (ETRAMP)
PFam PF09716 Early transcribed membrane protein (ETRAMP)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12686607 etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface. Spielmann T, Fergusen DJ, Beck HP 10.1091/mbc.e02-04-0240