Genome location: Pf3D7_11_v3:129,265..132,824(-)
Genome classification: Core
Product Description: early transcribed membrane protein 11.2
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020005 | symbiont-containing vacuole membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 5.20 | 0.00 |
| Trophozoite | expressed | 2.65 | 0.12 |
| Schizont | expressed | 2.50 | 0.11 |
| Gametocyte | expressed | 1.77 | 0.33 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1102800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.128 | MFS: -3.558 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0524800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIX3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 94
Non-coding: 79 | Synonymous: 8 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 94 | Molecular Weight (kDa): 10.231
UniProt ID(s): Q8IIX3
PDB ID(s): None
Isoelectric Point: 10.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12686607 | etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface. | Spielmann T, Fergusen DJ, Beck HP | 10.1091/mbc.e02-04-0240 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 37461081 | Reduced polymorphism of Plasmodium vivax early transcribed membrane protein(PvETRAMP) 11.2 | Perrotti E, L'Episcopia M, ..., Severini C | 10.1186/s13071-023-05851-9 |
| 23201113 | Systematic analysis of natural antibody responses to P. falciparum merozoiteantigens by protein arrays | Fan YT, Wang Y, ..., Chen JH | 10.1016/j.jprot.2012.11.020 |
| 26091354 | An immunomics approach for the analysis of natural antibody responses toPlasmodium vivax infection | Chen JH, Chen SB, ..., Hu W | 10.1039/c5mb00330j |