Product Description: 60S acidic ribosomal protein P1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0030295 | protein kinase activator activity |
| Function | GO:0043021 | ribonucleoprotein complex binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.80 | 0.33 |
| Trophozoite | expressed | 2.65 | 0.08 |
| Schizont | expressed | 0.62 | 0.67 |
| Gametocyte | expressed | 1.52 | 0.31 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1103100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.165 | MFS: -3.15 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0943600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIX0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101037
Most Similar Human Ortholog: P05386
TM-align score: 0.56 | RMSD: 2.72
Seq Identity: 0.42 | Length: 74 / 118
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137818 | ribosomal protein lateral stalk subunit P1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 66
Non-coding: 64 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 118 | Molecular Weight (kDa): 13.014
UniProt ID(s): Q8IIX0
PDB ID(s): None
Isoelectric Point: 4.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR027534 | Ribosomal protein L12 family |
| PFam | PF00428 | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25450178 | In vivo formation of Plasmodium falciparum ribosomal stalk - a unique mode ofassembly without stable heterodimeric intermediates. | Wawiorka L, Krokowski D, ..., Tchorzewski M | 10.1016/j.bbagen.2014.10.015 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 36760653 | Analysis of the role of BrRPP1 gene in Chinese cabbage infected by Plasmodiophorabrassicae | Ge W, Lv M, ..., Ji R | 10.3389/fpls.2023.1082395 |