About Gene List

PF3D7_1103400 (SufD)

Genome location: Pf3D7_11_v3:145,836..151,037(+)

Genome classification: Core

Function and Localization

Product Description: iron-sulfur cluster assembly protein SufD

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:1990229 iron-sulfur cluster assembly complex
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.20 0.90
Trophozoite possibly expressed 1.10 0.45
Schizont expressed 0.33 0.81
Gametocyte not expressed 0.58 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1103400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.205 | MFS: -2.678 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0943500)

  • Relative Growth Rate: 0.16 ± 0.12
  • Confidence: 5.67

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0943500)

Modification: Tagged | RMgm-989

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIW9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108643

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 55 36 69
disruptive 41 107 60 174
missense 25 94 52 139

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 99 56 67
disruptive 78 224 110 254
missense 44 180 88 188

PlasmoDB Total SNPs: 182

Non-coding: 55 | Synonymous: 77 | Nonsynonymous: 49 | Stop Codon: 1

Protein Information

Protein Length: 1462 | Molecular Weight (kDa): 172.391

UniProt ID(s): Q8IIW9

PDB ID(s): None

Isoelectric Point: 8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000825 SUF system FeS cluster assembly, SufBD
InterPro IPR011542 SUF system FeS cluster assembly, SufD
InterPro IPR037284 SUF system FeS cluster assembly, SufBD superfamily
PFam PF01458 SUF system FeS cluster assembly, SufBD
Superfamily SSF101960 SUF system FeS cluster assembly, SufBD superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
24586983 Identification of vital and dispensable sulfur utilization factors in thePlasmodium apicoplast. Haussig JM, Matuschewski K, Kooij TW 10.1371/journal.pone.0089718
28695709 [Fe-S] cluster assembly in the apicoplast and its indispensability in mosquitostages of the malaria parasite. Charan M, Choudhary HH, ..., Habib S 10.1111/febs.14159
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895