PF3D7_1103500

Genome location: Pf3D7_11_v3:151,196..154,519(-)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MKKCISLIFVLFINKIVG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044312	crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.03	0.98
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	1.35	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1103500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.039 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0943400)

Relative Growth Rate: 0.89 ± 0.23
Confidence: 4.35

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0943400)

Modification: Tagged | RMgm-4857

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIW8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_159552

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	32	24	44
disruptive	13	45	32	61
missense	13	45	31	59

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	70	32	49
disruptive	24	91	50	125
missense	23	84	44	101

PlasmoDB Total SNPs: 270

Non-coding: 219 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 583 | Molecular Weight (kDa): 67.274

UniProt ID(s): Q8IIW8

PDB ID(s): None

Isoelectric Point: 6.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
32736136	Plasmodium berghei LAPs form an extended protein complex that facilitatescrystalloid targeting and biogenesis.	Tremp AZ, Saeed S, ..., Dessens JT	10.1016/j.jprot.2020.103925