Product Description: CCR4-NOT transcription complex subunit NOT1-G, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0030015 | CCR4-NOT core complex |
| Component | GO:0000932 | P-body |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0060090 | molecular adaptor activity |
| Process | GO:0017148 | negative regulation of translation |
| Process | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.47 | 0.81 |
| Trophozoite | expressed | 1.39 | 0.36 |
| Schizont | expressed | 1.04 | 0.50 |
| Gametocyte | expressed | 1.79 | 0.26 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1103800
Resistome Missense Mutations: N1987K
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 3 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.505 | #Insertions: 14
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1025500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0945600)
Modification: Tagged | RMgm-5094
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101511
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3371
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125107 | CCR4-NOT transcription complex subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 44 | 183 | 97 | 217 |
| disruptive | 174 | 477 | 238 | 550 |
| missense | 86 | 354 | 185 | 439 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 79 | 338 | 148 | 210 |
| disruptive | 292 | 911 | 398 | 823 |
| missense | 142 | 684 | 317 | 552 |
PlasmoDB Total SNPs: 561
Non-coding: 188 | Synonymous: 237 | Nonsynonymous: 134 | Stop Codon: 2
Protein Length: 3371 | Molecular Weight (kDa): 391.942
UniProt ID(s): Q8IIW4
PDB ID(s): None
Isoelectric Point: 7.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007196 | CCR4-Not complex component, Not1, C-terminal |
| InterPro | IPR024557 | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 |
| InterPro | IPR032193 | CCR4-NOT transcription complex subunit 1, TTP binding domain |
| InterPro | IPR040398 | CCR4-NOT transcription complex subunit 1 |
| PFam | PF04054 | CCR4-Not complex component, Not1, C-terminal |
| PFam | PF12842 | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 |
| PFam | PF16417 | CCR4-NOT transcription complex subunit 1, TTP binding domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30703164 | Plasmodium male gametocyte development and transmission are critically regulatedby the two putative deadenylases of the CAF1/CCR4/NOT complex. | Hart KJ, Oberstaller J, ..., Lindner SE | 10.1371/journal.ppat.1007164 |
| 34673764 | The Plasmodium NOT1-G paralogue is an essential regulator of sexual stagematuration and parasite transmission. | Hart KJ, Power BJ, ..., Lindner SE | 10.1371/journal.pbio.3001434 |
| 38352447 | Global Release of Translational Repression Across Plasmodium's Host-to-VectorTransmission Event | Rios KT, McGee JP, ..., Lindner SE | 10.1101/2024.02.01.577866 |