PF3D7_1103900

Genome location: Pf3D7_11_v3:175,047..175,501(+)

Genome classification: Core

Function and Localization

Product Description: RIIa domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.13	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1103900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.998 | MFS: -1.755 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIW3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_206998

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	3	3
disruptive	1	12	4	15
missense	1	12	4	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	8	2	4
disruptive	3	23	8	15
missense	3	22	7	14

PlasmoDB Total SNPs: 24

Non-coding: 24 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 61 | Molecular Weight (kDa): 7.387

UniProt ID(s): Q8IIW3

PDB ID(s): None

Isoelectric Point: 4.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003117	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
PFam	PF02197	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Superfamily	SSF47391	N/A