Product Description: syntaxin, Qa-SNARE family
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031201 | SNARE complex |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0020020 | food vacuole |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.20 | 0.47 |
| Trophozoite | expressed | 0.72 | 0.60 |
| Schizont | expressed | 0.30 | 0.82 |
| Gametocyte | possibly expressed | 0.45 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1104100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.643 | MFS: -2.567 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0942800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIW1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 23 | 13 | 23 |
| disruptive | 1 | 26 | 22 | 40 |
| missense | 1 | 24 | 22 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 44 | 8 | 21 |
| disruptive | 8 | 68 | 51 | 85 |
| missense | 6 | 58 | 45 | 62 |
PlasmoDB Total SNPs: 199
Non-coding: 167 | Synonymous: 24 | Nonsynonymous: 7 | Stop Codon: 1
Protein Length: 347 | Molecular Weight (kDa): 41.388
UniProt ID(s): B5SPA1, Q0ZAE9, Q8IIW1
PDB ID(s): None
Isoelectric Point: 6.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006011 | Syntaxin, N-terminal domain |
| InterPro | IPR010989 | SNARE |
| PFam | PF14523 | Syntaxin, N-terminal domain |
| Superfamily | SSF47661 | SNARE |
| Superfamily | SSF58038 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17240462 | Identification of Plasmodium falciparum family of SNAREs. | Ayong L, Pagnotti G, Tobon AB, Chakrabarti D | https://pubmed.ncbi.nlm.nih.gov/17240462/ |
| 19103232 | Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasmamembrane Qa-SNARE. | Parish LA, Rayner JC | 10.1016/j.molbiopara.2008.11.011 |