Product Description: chromatin remodeling protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0008094 | ATP-dependent activity, acting on DNA |
| Function | GO:0003677 | DNA binding |
| Function | GO:0004386 | helicase activity |
| Process | GO:0006338 | chromatin remodeling |
| Process | GO:0016584 | nucleosome positioning |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.16 | 0.50 |
| Trophozoite | expressed | 1.18 | 0.43 |
| Schizont | expressed | 0.94 | 0.53 |
| Gametocyte | not expressed | 0.80 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1104200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -2.968 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0942700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0942700)
Modification: Tagged | RMgm-4671
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIW0
"Best" AlphaFill ligand hit: KEG (12-tungstophosphate, Local RMSD=0.07) with 5SUQ (Global RMSD=4.01)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P51531 | Probable global transcription activator SNF2L2 | Homo sapiens | OrthoDB | MLS000554093MLS000578788MLS000765838MLS000332963... |
| P51532 | Transcription activator BRG1 | Homo sapiens | OrthoDB | US10308614, Example 1US10308614, Example 2US10308614, Example 31-(4-(3-amino-6-(2-... |
Ortholog Group (OrthoMCL): OG6_100877
Most Similar Human Ortholog: A0A0A0MRP6
TM-align score: 0.55 | RMSD: 4.68
Seq Identity: 0.45 | Length: 637 / 1426
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102038 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
| ENSG00000153147 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 |
Protein Length: 1426 | Molecular Weight (kDa): 167.441
PDB ID(s): None
Isoelectric Point: 6.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000330 | SNF2-related, N-terminal domain |
| InterPro | IPR001650 | Helicase, C-terminal |
| InterPro | IPR009057 | Homeobox-like domain superfamily |
| InterPro | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00176 | SNF2-related, N-terminal domain |
| PFam | PF00271 | Helicase, C-terminal |
| Superfamily | SSF46689 | Homeobox-like domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 80 | 49 | 88 |
| disruptive | 34 | 133 | 60 | 146 |
| missense | 26 | 125 | 55 | 114 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 190 | 62 | 78 |
| disruptive | 60 | 254 | 97 | 258 |
| missense | 45 | 219 | 80 | 165 |
PlasmoDB Total SNPs: 210
Non-coding: 78 | Synonymous: 76 | Nonsynonymous: 56 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |