About Gene List

PF3D7_1104300

Genome location: Pf3D7_11_v3:190,492..195,121(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.12 0.94
Trophozoite expressed 0.76 0.60
Schizont expressed 0.31 0.82
Gametocyte expressed 0.99 0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1104300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.949 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIV9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104815

Most Similar Human Ortholog: B0QYG7

TM-align score: 0.61 | RMSD: 3.10

Seq Identity: 0.04 | Length: 117 / 1141

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100266 protein kinase C and casein kinase substrate in neurons 2
ENSG00000124507 protein kinase C and casein kinase substrate in neurons 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 68 41 62
disruptive 95 194 87 198
missense 47 135 65 147

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 121 45 77
disruptive 147 363 132 316
missense 68 253 96 187

PlasmoDB Total SNPs: 282

Non-coding: 125 | Synonymous: 86 | Nonsynonymous: 71 | Stop Codon: 0

Protein Information

Protein Length: 1141 | Molecular Weight (kDa): 136.504

UniProt ID(s): Q8IIV9

PDB ID(s): None

Isoelectric Point: 4.84

Protein Domain Annotations:

Source Family ID Description
InterPro IPR027267 AH/BAR domain superfamily
PFam N/A N/A
Superfamily SSF103657 AH/BAR domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108