Genome location: Pf3D7_11_v3:196,227..198,859(+)
Genome classification: Core
Product Description: thioredoxin-like mero protein
SignalP Peptide: MKTNIFSCVISFFILLLFCKA
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005634 | nucleus |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0046812 | host cell surface binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.42 | 0.80 |
| Trophozoite | expressed | 1.10 | 0.45 |
| Schizont | expressed | 0.44 | 0.75 |
| Gametocyte | expressed | 0.52 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1104400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.136 | MFS: -3.098 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0942500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIV8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 10 | 35 |
| disruptive | 3 | 17 | 10 | 24 |
| missense | 3 | 17 | 10 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 47 | 24 | 25 |
| disruptive | 8 | 37 | 39 | 45 |
| missense | 6 | 30 | 30 | 30 |
PlasmoDB Total SNPs: 204
Non-coding: 184 | Synonymous: 17 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 424 | Molecular Weight (kDa): 49.266
UniProt ID(s): Q8IIV8
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00085 | Thioredoxin domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 29844242 | A Thioredoxin Homologous Protein of Plasmodium falciparum Participates in Erythrocyte Invasion | Wang W, Huang P, ..., Chen Q | 10.1128/IAI.00289-18 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |