PF3D7_1104500

Genome location: Pf3D7_11_v3:199,103..201,037(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.57	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1104500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.578 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIV7

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=18.88) with 4JLV (Global RMSD=20.49)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215353

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	26	20	41
disruptive	18	66	54	114
missense	15	64	51	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	64	24	42
disruptive	35	167	76	128
missense	25	146	69	105

PlasmoDB Total SNPs: 32

Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 644 | Molecular Weight (kDa): 76.078

UniProt ID(s): Q8IIV7

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily