PF3D7_1104600

Genome location: Pf3D7_11_v3:202,330..204,261(+)

Genome classification: Core

Function and Localization

Product Description: radial spoke head protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Process	GO:0035082	axoneme assembly
Process	GO:0003341	cilium movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.07	0.96
Schizont	possibly expressed	0.04	0.98
Gametocyte	expressed	0.55	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1104600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.322 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0942300)

Relative Growth Rate: 0.77 ± 0.38
Confidence: 3.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0942300)

Modification: Disrupted | RMgm-2686

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIV6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102738

Most Similar Human Ortholog: M0R103

TM-align score: 0.68 | RMSD: 3.98

Seq Identity: 0.23 | Length: 363 / 643

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000104941	radial spoke head 6 homolog A
ENSG00000111834	radial spoke head component 4A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	36	16	41
disruptive	41	135	82	117
missense	25	107	62	92

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	67	28	50
disruptive	80	263	87	193
missense	48	198	67	133

PlasmoDB Total SNPs: 83

Non-coding: 0 | Synonymous: 48 | Nonsynonymous: 34 | Stop Codon: 1

Protein Information

Protein Length: 643 | Molecular Weight (kDa): 75.901

UniProt ID(s): Q8IIV6

PDB ID(s): None

Isoelectric Point: 5.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006802	Radial spokehead-like protein
PFam	PF04712	Radial spokehead-like protein
Superfamily	N/A	N/A