PF3D7_1104800

Genome location: Pf3D7_11_v3:206,335..210,051(+)

Genome classification: Core

Function and Localization

Product Description: metabolite/drug transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.08	0.96
Trophozoite	expressed	0.29	0.82
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1104800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.186 | MFS: -2.767 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0942100)

Relative Growth Rate: 0.07 ± 0.05
Confidence: 7.23

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIV4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_108621

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	33	16	35
disruptive	0	8	6	43
missense	0	8	4	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	67	18	34
disruptive	6	42	36	105
missense	1	29	30	64

PlasmoDB Total SNPs: 250

Non-coding: 221 | Synonymous: 29 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 417 | Molecular Weight (kDa): 49.28

UniProt ID(s): Q8IIV4

PDB ID(s): None

Isoelectric Point: 9.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR036259	MFS transporter superfamily
PFam	PF07690	Major facilitator superfamily
Superfamily	SSF103473	MFS transporter superfamily