Product Description: histone H4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0000786 | nucleosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Process | GO:0051276 | chromosome organization |
| Process | GO:0006334 | nucleosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.75 | 0.67 |
| Trophozoite | expressed | 2.56 | 0.16 |
| Schizont | expressed | 3.95 | 0.01 |
| Gametocyte | expressed | 1.49 | 0.39 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1105000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.261 | MFS: -3.385 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0941900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIV2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100120
Most Similar Human Ortholog: P62805
TM-align score: 0.79 | RMSD: 2.62
Seq Identity: 0.82 | Length: 102 / 103
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158406 | H4 clustered histone 8 |
| ENSG00000197061 | H4 clustered histone 3 |
| ENSG00000197238 | H4 clustered histone 11 |
| ENSG00000197837 | H4 histone 16 |
| ENSG00000270276 | H4 clustered histone 15 |
| ENSG00000270882 | H4 clustered histone 14 |
| ENSG00000273542 | H4 clustered histone 12 |
| ENSG00000274618 | H4 clustered histone 6 |
| ENSG00000275126 | H4 clustered histone 13 |
| ENSG00000276180 | H4 clustered histone 9 |
| ENSG00000276966 | H4 clustered histone 5 |
| ENSG00000277157 | H4 clustered histone 4 |
| ENSG00000278637 | H4 clustered histone 1 |
| ENSG00000278705 | H4 clustered histone 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 253
Non-coding: 253 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 103 | Molecular Weight (kDa): 11.456
UniProt ID(s): O00882, Q7JSX6, Q8IIV2
PDB ID(s): None
Isoelectric Point: 11.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001951 | Histone H4 |
| InterPro | IPR004823 | TATA box binding protein associated factor (TAF) |
| InterPro | IPR009072 | Histone-fold |
| InterPro | IPR019809 | Histone H4, conserved site |
| InterPro | IPR035425 | CENP-T/Histone H4, histone fold |
| PFam | PF15511 | CENP-T/Histone H4, histone fold |
| Superfamily | SSF47113 | Histone-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15820676 | Telomeric heterochromatin propagation and histone acetylation control mutuallyexclusive expression of antigenic variation genes in malaria parasites. | Freitas-Junior LH, Hernandez-Rivas R, ..., Scherf A | 10.1016/j.cell.2005.01.037 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29101771 | Modifications at K31 on the lateral surface of histone H4 contribute to genomestructure and expression in apicomplexan parasites | Sindikubwabo F, Ding S, ..., Hakimi MA | 10.7554/eLife.29391 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38423406 | Platycodon grandiflorus polysaccharide inhibits the inflammatory response of3D4/21_cells infected with PCV2 | Guo X, Zhao X, ..., Zhao X | 10.1016/j.micpath.2024.106592 |