About Gene List

PF3D7_1105200 (WDR8)

Genome location: Pf3D7_11_v3:228,159..231,014(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein WRAP73, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:1990811 MWP complex
Component GO:0005815 microtubule organizing center
Component GO:0072686 mitotic spindle
Process GO:0000070 mitotic sister chromatid segregation
Process GO:1902440 protein localization to mitotic spindle pole body

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.07 0.97
Trophozoite possibly expressed 0.11 0.94
Schizont not expressed 0.09 0.94
Gametocyte possibly expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1105200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -1.389 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIV0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103893

Most Similar Human Ortholog: Q5TBW1

TM-align score: 0.91 | RMSD: 1.80

Seq Identity: 0.16 | Length: 177 / 463

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000116213 WD repeat containing, antisense to TP73

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 39 16 35
disruptive 7 57 30 79
missense 6 54 27 72

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 64 27 38
disruptive 16 127 53 123
missense 12 107 48 90

PlasmoDB Total SNPs: 177

Non-coding: 143 | Synonymous: 21 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 463 | Molecular Weight (kDa): 54.224

UniProt ID(s): Q8IIV0

PDB ID(s): None

Isoelectric Point: 8.62

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036322 WD40-repeat-containing domain superfamily
PFam N/A N/A
Superfamily SSF50978 WD40-repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25987607 The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeastspindle pole bodies Yukawa M, Ikebe C, Toda T 10.1083/jcb.201412111