Product Description: 40S ribosomal protein S4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.89 | 0.30 |
| Trophozoite | expressed | 2.32 | 0.14 |
| Schizont | expressed | 0.46 | 0.74 |
| Gametocyte | expressed | 1.09 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1105400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.943 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIU8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100732
Most Similar Human Ortholog: P22090
TM-align score: 0.99 | RMSD: 0.62
Seq Identity: 0.57 | Length: 261 / 261
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000129824 | ribosomal protein S4 Y-linked 1 |
| ENSG00000198034 | ribosomal protein S4 X-linked |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 206
Non-coding: 195 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 261 | Molecular Weight (kDa): 29.772
UniProt ID(s): Q8IIU8
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000876 | Ribosomal protein S4e |
| InterPro | IPR005824 | KOW |
| InterPro | IPR013843 | Ribosomal protein S4e, N-terminal |
| InterPro | IPR013845 | Ribosomal protein S4e, central region |
| InterPro | IPR018199 | Ribosomal protein S4e, N-terminal, conserved site |
| InterPro | IPR032277 | 40S ribosomal protein S4, C-terminal domain |
| InterPro | IPR041982 | Ribosomal protein S4, KOW domain |
| PFam | PF00467 | KOW |
| PFam | PF00900 | Ribosomal protein S4e, central region |
| PFam | PF08071 | Ribosomal protein S4e, N-terminal |
| PFam | PF16121 | 40S ribosomal protein S4, C-terminal domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 37751644 | Screening of genes encoding proteins that interact with Nrf2: Probing a cDNAlibrary from Mytilus coruscus using a yeast two-hybrid system | Zhu L, Li Y, ..., Qi P | 10.1016/j.fsi.2023.109112 |