Product Description: centrin-4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005815 | microtubule organizing center |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0030234 | enzyme regulator activity |
| Process | GO:0019722 | calcium-mediated signaling |
| Process | GO:0000226 | microtubule cytoskeleton organization |
| Process | GO:0000278 | mitotic cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.96 |
| Trophozoite | expressed | 0.42 | 0.75 |
| Schizont | expressed | 0.26 | 0.83 |
| Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1105500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -3.291 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I714
"Best" AlphaFill ligand hit: TAM (tris(hydroxyethyl)aminomethane, Local RMSD=0.19) with 2YGG (Global RMSD=8.47)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 227
Non-coding: 222 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 171 | Molecular Weight (kDa): 20.103
UniProt ID(s): Q8I714
PDB ID(s): None
Isoelectric Point: 4.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002048 | EF-hand domain |
| InterPro | IPR011992 | EF-hand domain pair |
| InterPro | IPR018247 | EF-Hand 1, calcium-binding site |
| PFam | PF13499 | EF-hand domain |
| Superfamily | SSF47473 | EF-hand domain pair |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18693242 | Centrins, cell cycle regulation proteins in human malaria parasite Plasmodiumfalciparum. | Mahajan B, Selvapandiyan A, ..., Kumar S | 10.1074/jbc.M800028200 |
| 30541825 | Plasmodium centrin Pb CEN-4 localizes to the putative M TOC and is dispensable formalaria parasite proliferation | Roques M, Stanway RR, ..., Tewari R | 10.1242/bio.036822 |
| 16233754 | A yeast artificial chromosome-splitting vector designed for precise manipulation of specific plant chromosome region | Kim Y, Kaneko Y, ..., Harashima S | 10.1263/jbb.99.55 |
| 15347651 | Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells | Giessl A, Pulvermuller A, ..., Wolfrum U | 10.1074/jbc.M406770200 |
| 23631908 | Comparison of two approaches for identification of haplotypes and point mutations in Candida albicans and Saccharomyces cerevisiae | Gomez-Raja J, Larriba G | 10.1016/j.mimet.2013.04.007 |
| 27589939 | Truncation of Gal4p explains the inactivation of the GAL/MEL regulon in both Saccharomyces bayanus and some Saccharomyces cerevisiae wine strains | Dulermo R, Legras JL, ..., Nguyen HV | 10.1093/femsyr/fow070 |
| 24055541 | Reprint of Comparison of two approaches for identification of haplotypes and point mutations in Candida albicans and Saccharomyces cerevisiae | Gomez-Raja J, Larriba G | 10.1016/j.mimet.2013.09.010 |
| 12904293 | Plasmid accumulation reduces life span in Saccharomyces cerevisiae | Falcon AA, Aris JP | 10.1074/jbc.M307025200 |