About Gene List

PF3D7_1105800

Genome location: Pf3D7_11_v3:250,276..253,352(+)

Genome classification: Core

Function and Localization

Product Description: conserved Apicomplexan protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020020 food vacuole
Component GO:0005739 mitochondrion
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.22 0.89
Trophozoite expressed 0.73 0.60
Schizont expressed 0.39 0.75
Gametocyte expressed 0.29 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1105800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.751 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0941100)

  • Relative Growth Rate: 0.10 ± nan
  • Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIU5

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=2.39) with 5OXF (Global RMSD=20.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131667

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 7 14 14
disruptive 1 7 2 12
missense 1 5 2 9

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 23 12 20
disruptive 6 16 18 66
missense 3 13 14 42

PlasmoDB Total SNPs: 163

Non-coding: 150 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 266 | Molecular Weight (kDa): 30.661

UniProt ID(s): Q8IIU5

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
21136929 Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, Tastet C, ..., Dubremetz JF 10.1002/prca.200700112
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0
27594426 A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. Sidik SM, Huet D, ..., Lourido S 10.1016/j.cell.2016.08.019