Product Description: conserved Apicomplexan protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020020 | food vacuole |
Component | GO:0005739 | mitochondrion |
Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.22 | 0.89 |
Trophozoite | expressed | 0.73 | 0.60 |
Schizont | expressed | 0.39 | 0.75 |
Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1105800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -2.751 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0941100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIU5
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=2.39) with 5OXF (Global RMSD=20.58)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 7 | 14 | 14 |
disruptive | 1 | 7 | 2 | 12 |
missense | 1 | 5 | 2 | 9 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 23 | 12 | 20 |
disruptive | 6 | 16 | 18 | 66 |
missense | 3 | 13 | 14 | 42 |
PlasmoDB Total SNPs: 163
Non-coding: 150 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 266 | Molecular Weight (kDa): 30.661
UniProt ID(s): Q8IIU5
PDB ID(s): None
Isoelectric Point: 4.74
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
27594426 | A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. | Sidik SM, Huet D, ..., Lourido S | 10.1016/j.cell.2016.08.019 |