PF3D7_1106100

Genome location: Pf3D7_11_v3:258,508..259,998(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S15, apicoplast, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.39	0.76
Schizont	expressed	0.24	0.85
Gametocyte	possibly expressed	0.64	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1106100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.169 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0940800)

Relative Growth Rate: 0.06 ± 0.04
Confidence: 7.70

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIU2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101240

Most Similar Human Ortholog: P82914

TM-align score: 0.43 | RMSD: 3.99

Seq Identity: 0.20 | Length: 136 / 269

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000116898	mitochondrial ribosomal protein S15

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	14	11	20
disruptive	4	26	8	28
missense	2	23	8	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	31	14	30
disruptive	10	58	31	86
missense	6	41	26	59

PlasmoDB Total SNPs: 74

Non-coding: 60 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 269 | Molecular Weight (kDa): 32.403

UniProt ID(s): Q8IIU2

PDB ID(s): None

Isoelectric Point: 10.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000589	Ribosomal protein S15
InterPro	IPR005290	Ribosomal protein S15, bacterial-type
InterPro	IPR009068	S15/NS1, RNA-binding
PFam	PF00312	Ribosomal protein S15
Superfamily	SSF47060	S15/NS1, RNA-binding

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895