Product Description: 5'-3' exoribonuclease 1, putative
SignalP Peptide: MIAFISLWVLCIINVMA
# Transmembrane Domains: 0
EC Numbers: 3.1.13.- (Exoribonucleases producing 5'-phosphomonoesters.);3.1.4.1 (Phosphodiesterase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005634 | nucleus |
| Function | GO:0004534 | 5'-3' exoribonuclease activity |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000956 | nuclear-transcribed mRNA catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.95 |
| Trophozoite | expressed | 0.79 | 0.56 |
| Schizont | expressed | 0.35 | 0.78 |
| Gametocyte | expressed | 0.50 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1106300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.222 | MFS: -2.887 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZZN7
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 30 | 20 | 47 |
| disruptive | 18 | 47 | 38 | 60 |
| missense | 7 | 27 | 31 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 65 | 33 | 67 |
| disruptive | 27 | 90 | 57 | 107 |
| missense | 11 | 64 | 47 | 86 |
PlasmoDB Total SNPs: 212
Non-coding: 138 | Synonymous: 49 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 733 | Molecular Weight (kDa): 87.293
UniProt ID(s): A0A143ZZN7
PDB ID(s): None
Isoelectric Point: 7.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004859 | Putative 5-3 exonuclease |
| InterPro | IPR016494 | 5'-3' exoribonuclease 1 |
| InterPro | IPR027073 | 5'-3' exoribonuclease |
| InterPro | IPR041412 | Xrn1, helical domain |
| PFam | PF03159 | Putative 5-3 exonuclease |
| PFam | PF17846 | Xrn1, helical domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 37746059 | Xrn1 biochemically associates with eisosome proteins after the post diauxic shiftin yeast | Courtin B, Namane A, ..., Fromont-Racine M | 10.17912/micropub.biology.000926 |
| 37667796 | The RNA helicases Dbp2 and Mtr4 regulate the expression of Xrn1-sensitive longnon-coding RNAs in yeast | Wery M, Szachnowski U, ..., Morillon A | 10.3389/frnar.2023.1244554 |
| 37808861 | Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability | McGinnis MM, Sutter BM, Jahangiri S, Tu BP | 10.1101/2023.09.28.559955 |
| 38197223 | LINE-1 mRNA 3' end dynamics shape its biology and retrotransposition potential | Janecki DM, Sen R, ..., Warkocki Z | 10.1093/nar/gkad1251 |
| 37749116 | Xrn1-resistant RNA motifs are disseminated throughout the RNA virome and are able to block scanning ribosomes | Dilweg IW, Peer J, Olsthoorn RCL | 10.1038/s41598-023-43001-4 |
| 38011112 | eIF2A represses cell wall biogenesis gene expression in Saccharomyces cerevisiae | Meyer L, Courtin B, ..., Fromont-Racine M | 10.1371/journal.pone.0293228 |
| 37621215 | The EDC4-XRN1 interaction controls P-body dynamics to link mRNA decapping with decay | Brothers WR, Ali F, Kajjo S, Fabian MR | 10.15252/embj.2023113933 |
| 37876592 | Structure and function of molecular machines involved in deadenylation-dependent 5'-3' mRNA degradation | Zhao Q, Pavanello L, Bartlam M, Winkler GS | 10.3389/fgene.2023.1233842 |