About Gene List

PF3D7_1106500

Genome location: Pf3D7_11_v3:268,176..274,697(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.32 0.85
Trophozoite expressed 0.77 0.58
Schizont expressed 0.12 0.93
Gametocyte not expressed 0.52 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1106500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.079 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIT8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_143205

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 29 89 52 113
disruptive 82 282 145 364
missense 44 195 115 301

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 44 181 75 131
disruptive 180 553 256 532
missense 97 402 187 368

PlasmoDB Total SNPs: 358

Non-coding: 57 | Synonymous: 162 | Nonsynonymous: 139 | Stop Codon: 0

Protein Information

Protein Length: 2021 | Molecular Weight (kDa): 240.471

UniProt ID(s): Q8IIT8

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895