PF3D7_1106900

Genome location: Pf3D7_11_v3:289,667..290,290(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.01	0.99
Gametocyte	possibly expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1106900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.132 | MFS: -2.926 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIT4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127981

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	5	12
disruptive	1	16	7	26
missense	1	16	7	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	15	8	13
disruptive	8	33	17	49
missense	7	25	16	33

PlasmoDB Total SNPs: 17

Non-coding: 10 | Synonymous: 1 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 168 | Molecular Weight (kDa): 20.354

UniProt ID(s): Q8IIT4

PDB ID(s): None

Isoelectric Point: 6.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A