Product Description: U6 snRNA-associated Sm-like protein LSm4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000932 | P-body |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005688 | U6 snRNP |
| Component | GO:0005634 | nucleus |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0017070 | U6 snRNA binding |
| Process | GO:0033962 | P-body assembly |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000387 | spliceosomal snRNP assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.98 |
| Trophozoite | expressed | 0.14 | 0.91 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1107000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.808 | MFS: -2.083 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0939900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIT3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102392
Most Similar Human Ortholog: Q9Y4Z0
TM-align score: 0.73 | RMSD: 2.04
Seq Identity: 0.47 | Length: 104 / 126
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130520 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 6 | 4 | 12 |
| disruptive | 3 | 9 | 6 | 12 |
| missense | 3 | 8 | 4 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 12 | 6 | 12 |
| disruptive | 4 | 23 | 13 | 35 |
| missense | 4 | 19 | 11 | 22 |
PlasmoDB Total SNPs: 66
Non-coding: 61 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 126 | Molecular Weight (kDa): 14.202
UniProt ID(s): Q8IIT3
PDB ID(s): None
Isoelectric Point: 10.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR027141 | Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 |
| InterPro | IPR034101 | Sm-like protein Lsm4 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37762007 | Yeast Lsm Pro-Apoptotic Mutants Show Defects in Autophagy | Caraba B, Stirpe M, ..., Mazzoni C | 10.3390/ijms241813708 |
| 29615482 | Defining essential elements and genetic interactions of the yeast Lsm2-8 ring anddemonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6snRNA or the U6 snRNP subunit Prp24 | Roth AJ, Shuman S, Schwer B | 10.1261/rna.066175.118 |
| 27543059 | The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together toenhance mRNA stability and alter mRNA decay pathway dependence in Saccharomycescerevisiae | Huch S, Muller M, ..., Nissan T | 10.1242/bio.020487 |
| 29078371 | Numerous interactions act redundantly to assemble a tunable size of P bodies inSaccharomyces cerevisiae | Rao BS, Parker R | 10.1073/pnas.1712396114 |
| 26582754 | Protein localisation by electron microscopy reveals the architecture of the yeastspliceosomal B complex | Rigo N, Sun C, ..., Luhrmann R | 10.15252/embj.201592022 |