PF3D7_1107200

Genome location: Pf3D7_11_v3:297,359..301,207(+)

Genome classification: Core

Function and Localization

Product Description: vacuolar fusion protein CCZ1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	expressed	0.58	0.66
Schizont	expressed	0.15	0.90
Gametocyte	expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1107200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.399 | MFS: -2.629 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIT1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103803

Most Similar Human Ortholog: P86791

TM-align score: 0.79 | RMSD: 2.90

Seq Identity: 0.21 | Length: 414 / 713

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000122674	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
ENSG00000146574	CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	47	29	53
disruptive	24	81	57	130
missense	20	74	52	112

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	106	33	63
disruptive	49	211	104	242
missense	34	175	85	161

PlasmoDB Total SNPs: 213

Non-coding: 170 | Synonymous: 21 | Nonsynonymous: 21 | Stop Codon: 1

Protein Information

Protein Length: 713 | Molecular Weight (kDa): 84.212

UniProt ID(s): Q8IIT1

PDB ID(s): None

Isoelectric Point: 8.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013176	Vacuolar fusion protein Ccz1
InterPro	IPR043987	CCZ1/INTU/HSP4, first Longin domain
PFam	PF19031	CCZ1/INTU/HSP4, first Longin domain
Superfamily	N/A	N/A