Product Description: polyadenylate-binding protein-interacting protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0098808 | mRNA cap binding |
| Function | GO:0003743 | translation initiation factor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.36 | 0.18 |
| Trophozoite | expressed | 2.15 | 0.16 |
| Schizont | expressed | 1.52 | 0.33 |
| Gametocyte | expressed | 1.75 | 0.25 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1107300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.463 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0939600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q04637 | Eukaryotic translation initiation factor 4 gamma 1 | Homo sapiens | OrthoDB | cid_646096cid_646406med.21724, Compound 153MLS000041608... |
Ortholog Group (OrthoMCL): OG6_101572
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3334
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000075151 | eukaryotic translation initiation factor 4 gamma 3 |
| ENSG00000114867 | eukaryotic translation initiation factor 4 gamma 1 |
Protein Length: 3334 | Molecular Weight (kDa): 381.872
UniProt ID(s): Q8IIS9
PDB ID(s): None
Isoelectric Point: 7.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003890 | MIF4G-like, type 3 |
| InterPro | IPR016024 | Armadillo-type fold |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 66 | 204 | 126 | 212 |
| disruptive | 202 | 599 | 271 | 720 |
| missense | 93 | 402 | 209 | 541 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 102 | 412 | 159 | 256 |
| disruptive | 384 | 1216 | 569 | 1194 |
| missense | 170 | 868 | 421 | 709 |
PlasmoDB Total SNPs: 918
Non-coding: 381 | Synonymous: 260 | Nonsynonymous: 277 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |